Biosynthesis of antibiotic A23187 incorporation of precursors into A23187.
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چکیده
منابع مشابه
The Journal of Antibiotics Biosynthesis of Antibiotic A23187 Incorporation of Precursors into A23187 Note
Streptomyces chartreusis NRRL 3881 produces the divalent cation ionophore antibiotic A231871). This antibiotic is primarily active against Grampositive bacteria and fungi and has been used extensively to investigate the role of divalent cations in regulating cellular physiological processes2,3,4). The chemical structure of A231875.6) indicates that it is a member of a new class of ionophorous a...
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Streptomyces go/diniensis produces aurodox 3) (1) and small amounts of its N-demethyl homolog mocimycin (2)4) which is probably identical 5) with kirromycin 6,7). These antibiotics and a recently discovered disaccharide derivative of aurodox (3)8) are primarily active against Grampositive bacteria and enhance the growth of farm animals. The chemical structures, including stereochemistry, have b...
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A23187 is a carboxylic acid antibiotic which simultaneously uncouples oxidative phosphorylation and inhibits ATPase of rat liver mitochondria incubated in a magnesium-free medium. The antibiotic acts as a freely mobile carrier to transport calcium and magnesium, but not potassium, from an aqueous medium buffered at pH 7.4 into a bulk organic phase. A23187 causes a progressive release of endogen...
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The crystal and molecular structures of the calcium complex of A23187 has been determined by X-ray diffraction studies.
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This study was designated to clarify the influence of activation of porcine matured oocytes by calcium ionophore on in vitro development of the parthenotes. The follicular oocytes were matured, activated and cultured in North Carolina State University-23 (NCSU-23) medium supplemented with 10% porcine follicular fluid (pFF). The in vitro-matured oocytes were exposed to calcium ionophore at conce...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1980
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.33.447